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. 2018 Jan 2;9:37. doi: 10.1038/s41467-017-02448-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Trpv1 mediates heat hyperalgesia during S. aureus infection. a Heat hyperalgesia was measured by the Hargreaves’ radiant heat test in resiniferatoxin (RTX) vs. vehicle-treated mice following S. aureus infection (1 × 10⁶ CFU, USA300). Forty seconds is the maximum cutoff for this assay. n = 12 mice per group. p values, two-way ANOVA with Sidak’s post-test. b Heat hyperalgesia measured in Trpv1^−/− compared to Trpv1^+/− or Trpv1^+/+ littermates following S. aureus infection. Statistical comparisons shown: Trpv1^−/− vs. Trpv1^+/+ littermates. p values, two-way ANOVA with Tukey’s post-test. n = 8–10 mice per group. c Spontaneous pain was quantified over 60 min in RTX or vehicle-treated mice infected with S. aureus (USA300, 5 × 10⁸ CFU). n = 5 mice per group. p values by unpaired t test. d Spontaneous pain was quantified over 60 min in Trpv1^−/− mice and littermate (Trpv1^+/−, Trpv1^+/+) controls in S. aureus-infected mice (USA300, 5 × 10⁸ CFU). n = 8 mice per group. a, c N = 2 replicates; b, d N = 3 replicates each. p values, one-way ANOVA, Tukey’s post-test. ****p < 0.0001; ***p < 0.001; **p < 0.01; *p < 0.05. Error bars throughout figure, mean ± s.e.m.