Fig. 2.

Increased type I interferon in skin lesions of paradoxical psoriasis. a mRNA expression analysis of pro-inflammatory cytokines TNF, IL6, IFNA2, IFNB1, IL36G, IL12A, IL23A, CXCL8, and IL1B relative to GAPDH in skin lesions of paradoxical psoriasis compared to classical plaque psoriasis. b mRNA expression analysis of adaptive T-cell-derived cytokines IL17A, IL17F, IL17C, IL22, IL26, IFNG, IL4, and IL10 relative to GAPDH in skin lesions of paradoxical psoriasis as compared to classical plaque psoriasis. Dots represent individual patient and horizontal bar denotes the median value. Data shown as mRNA expression level relative to mean expression in classical psoriasis (mean value for classical psoriasis was set at 1). Statistical analysis was performed with unpaired non-parametric Mann–Whitney U-test. ND = not detected