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. 2018 Jan 2;9:10. doi: 10.1038/s41467-017-02449-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — The Poly(A) SPOT-ON reduces pain sensitization produced by capsaicin. a The Poly(A) SPOT-ON (10 μg) inhibits the mechanical hypersensitivity produced by intraplantar capsaicin (5 μg) and b blocks the development of hyperalgesic priming. CGRP_8–37 (1 μg) has a transient antinociceptive effect at 3 h post capsaicin with no changes after the precipitation of priming with PGE₂. *P < 0.05, **P < 0.01, significantly different from scramble SPOT-ON+capsaicin (CAP) group analyzed by two-way ANOVA followed by Bonferroni post hoc test. c The Poly(A) SPOT-ON and CGRP_8–37 attenuate the thermal hypersensitivity produced by capsaicin. *P < 0.05, significantly different from Poly(A) SPOT-ON+capsaicin (CAP) group and ^& P < 0.05, significantly different from baseline (BL) analyzed by two-way ANOVA followed by Bonferroni post hoc test. Not significantly different (NS) compared to baseline (BL). d No changes in thermal hypersensitivity are detected after priming revealed by PGE₂. e The Poly(A) SPOT-ON and CGRP_8–37 block the transient increase in paw temperature produced by intraplantar capsaicin administration. **P < 0.01, significantly different from the non-injected paw or the Poly(A) SPOT-ON injected paw analyzed by one-way ANOVA followed by Bonferroni post hoc test. Not significantly different (NS) compared to non-injected paw. f No changes in paw temperature are present after priming (injected vs. non-injected paw). n = 6 per group. For all graphs shown in the figure, data are plotted as mean ± s.e.m.