Table 1.

Maximum tolerated dose of APA:siRNA-miRNA polyplex

N/P ratio	siRNA dose (mg kg–1)	miRNA dose (mg kg–1)	Total RNA dose (mg kg–1)	Polymer dose (mg kg–1)	Survival
2	3	3	6	16.07	+
	2	2	4	10.7	+
	1	1	2	5.3	+
	0.5	0.5	1	2.6	+