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. 2018 Jan 2;9:6. doi: 10.1038/s41467-017-02251-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Systemic inflammatory toxicity mainly derived from IL-2-Fc rather than anti-CD137. Groups of C57Bl/6 mice (n = 4/group) were inoculated with 5 × 10⁵ B16F10 tumor cells s.c. on day 0, then received i.v. injections of αCD137 and IL-2-Fc (αCD137/IL-2-Fc), Lipo-IL-2-Fc mixed with αCD137 (Lipo-IL-2-Fc/αCD137), or Lipo-αCD137 mixed with IL-2-Fc (Lipo- αCD137/IL-2-Fc) on day 8. One day later, sera were collected from peripheral blood and levels of IFNγ (a), IL-6 (b), MCP-1 (c) and TNFα (d) were assayed by luminex assays. All measurements shown are mean ± s.e.m.