Fig. 5.

ProTxII significantly reduces sEPSC frequency following burn injury. The effect of ProTxII sEPSC frequency recorded from the spinal superficial dorsal horn neurons. In the slices with the sham treatment (n = 9), the basal sEPSC frequency was low and ProTxII (10 nM) did not produce any change (a, b, sham). Neurons in slices prepared after the burn injury (n = 10) exhibited a robust increase in sEPSCs (a, burn injury), and the application of ProTxII induced a significant decrease of the sEPSC frequency (a, b, **p = 0.006). The basal sEPSC frequency in the sham group and the burn injury group was significantly different (b, ##p = 0.002)