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. 2017 Aug 1;9(1):74–91. doi: 10.1007/s12975-017-0559-x

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Experimental designs. a Experiment 1 was designed to investigate the effect of melatonin treatment on ICH-induced secondary brain injury (SBI) in vivo. b Experiment 2 was designed to investigate the effect of melatonin treatment on ICH-induced SBI in vitro. c Coronal sections of brain tissues after 72 h post-ICH induction