TABLE 2 .
Trabecular and cortical bone parameters for humanized Swiss Webster micea
| Bone type, parameter | Mean value ± SEM for samples from mice receiving indicated microbiota (no. of mice) |
P value | ||||
|---|---|---|---|---|---|---|
| GF (7) | A (6) | B (7) | C (3) | CONV-D (4) | ||
| Trabecular | ||||||
| BV/TV (%) | 30.84 ± 2.40 | 32.80 ± 1.94 | 30.93 ± 3.58 | 31.45 ± 1.51 | 29.50 ± 4.50 | 0.88 |
| BMD (mg/cm3) | 225.82 ± 30.04 | 246.25 ± 25.52 | 228.57 ± 53.03 | 234.66 ± 20.42 | 220.01 ± 41.30 | 0.83 |
| Tb. Th. (μm) | 5.74 ± 0.71 | 6.44 ± 0.25 | 5.87 ± 1.20 | 6.11 ± 0.75 | 5.79 ± 0.56 | 0.64 |
| Tb. N. (mm−1) | 5.32 ± 0.72 | 5.03 ± 0.44 | 5.18 ± 1.01 | 5.12 ± 0.56 | 5.03 ± 1.10 | 0.98 |
| Tb. sp. (μm) | 133.49 ± 24.01 | 135.50 ± 19.41 | 139.58 ± 35.80 | 135.90 ± 15.14 | 148.18 ± 45.04 | 0.96 |
| Cortical | ||||||
| Ct. volume (mm3) | 0.98 ± 0.01 | 0.98 ± 0.01 | 0.98 ± 0.01 | 0.97 ± 0.01 | 0.97 ± 0.01 | 0.08 |
| Ct. thickness (μm) | 285.57 ± 17.64 | 303.20 ± 20.46 | 301.67 ± 6.80 | 276.00 ± 12.77 | 277.50 ± 16.28 | 0.19 |
| BMD (mg/cm3) | 1,039.43 ± 8.02 | 1,015.99 ± 1.43 | 1,041.60 ± 12.61 | 1,041.50 ± 4.46 | 1,042.04 ± 18.93 | 0.97 |
| MOI (mm4) | 0.11 ± 0.03 | 0.09 ± 0.01 | 0.10 ± 0.01 | 0.08 ± 0.04 | 0.09 ± 0.01 | 0.30 |
| Body weight (g) | 35.04 ± 2.40 | 32.01 ± 1.17 | 33.45 ± 0.96 | 32.75 ± 1.15 | 31.74 ± 1.09 | 0.78 |
| Femur length (mm) | 17.22 ± 0.24 | 17.35 ± 0.26 | 17.21 ± 0.13 | 17.09 ± 0.14 | 17.10 ± 0.21 | 0.82 |
a
This table summarizes data from the experiment described in the legend to Fig. 1.