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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Immunol Rev. 2018 Jan;281(1):5–7. doi: 10.1111/imr.12624

Figure 1. IL-1 Family Has Evolved to Balance Itself.

Figure 1

The IL-1 Family provides innate inflammation that is required for non-specific host defense as well as acquired immunity. Inflammation non-specifically contributes to host defense by increasing core temperature, white blood cell infiltration and microbial killing. Acquired immunity specifically contributes to host defense by acting as an adjuvant for Tcells and Bcells. Runaway inflammation and autoreactive Tcell activity is controlled by IL-1 Family members IL-1Ra, IL-36Ra, IL-37, IL-38 and IL-18BP.