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. Author manuscript; available in PMC: 2018 Jan 3.
Published in final edited form as: Nat Med. 2016 Sep 5;22(10):1151–1159. doi: 10.1038/nm.4173

Figure 1.

Figure 1

Overactive peripheral chemoreceptors in spontaneously hypertensive (SH) rats. Original recordings of carotid sinus nerve (CSN; (a)) activity showing both basal discharge (a,b) and that evoked reflexly by stimulating the carotid body with sodium cyanide (a,c; 22.5 μg NaCN i.a., arrowed in a) in SH and Wistar rats. CSN data from the in situ perfused preparation. (one-way ANOVA Bonferroni post-test; n = 10 or 11, ***P < 0.001). (d), dopamine infusion (10 μg/kg/min i.v.) while recording ventilation frequency in conscious radio-telemetered Wistar and SH rats (n = 5 each) before and after selective carotid body resection (SHR CBR). One-way ANOVA Dunnett’s post-test. * P < 0.05. ***P < 0.001. All data are mean ± s.e.m.