TABLE 1 .
IC | Result (mM) fora: |
|||||
---|---|---|---|---|---|---|
LASV |
LCMV |
|||||
ICWT | ICKO | Δ = ICWT − ICKO | ICWT | ICKO | Δ = ICWT − ICKO | |
IC25 | 0.48 ± 0.08 | 0.30 ± 0.21 | 0.18 ± 0.14 | 0.32 ± 0.01 | 0.17 ± 0.01 | 0.15 ± 0.00 |
IC50 | 1.17 ± 0.15 | 0.51 ± 0.26 | 0.65 ± 0.12 | 0.64 ± 0.04 | 0.39 ± 0.02 | 0.25 ± 0.03 |
IC75 | 2.57 ± 0.31 | 0.89 ± 0.28 | 1.68 ± 0.03 | 1.24 ± 0.12 | 0.87 ± 0.04 | 0.36 ± 0.08 |
IC80 | 3.07 ± 0.39 | 1.03 ± 0.28 | 2.04 ± 0.11 | 1.45 ± 0.15 | 1.06 ± 0.05 | 0.39 ± 0.10 |
IC90 | 4.65 ± 0.70 | 1.53 ± 0.28 | 3.12 ± 0.45 | 2.16 ± 0.26 | 1.73 ± 0.09 | 0.43 ± 0.17 |
Data are the averages ± SD from three experiments. The differences between the WT and KO values for both LASV and LCMV are shown graphically in Fig. 7C.