Table 1. Major genome-wide association studies in AS.

Study	Year	Discovery cohort (case/control)	Coverage/variant types	Ethnicity	No. of non-MHC variants reaching genome-wide significance
Burton et al. (WTCCC & TASC)46	2007	1000/1500	Non-synonymous variants only	European	2
Reveille et al. (TASC)30	2010	2053/5140	GWAS	European	4
Evans et al. (TASC)47	2011	3023/8779	GWAS	European	8
Lin et al.49	2011	1965/4301	GWAS	Han Chinese	3
Cortes et al. (IGAS)20	2013	10,619/15,145	Illumina Immunochip	European, East Asian and Latin American	24
Robinson et al.48	2016	5040/21,133	Illumina Exomechip	European	2
Ellinghaus et al.19	2016	8726/34,213	Illumina Immunochip	European and East Asian	113

Abbreviation: MHC, major histocompatibility complex.