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. 2017 Dec 20;6(12):e116. doi: 10.1038/emi.2017.106

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Kinetics and magnitude of ScaA- and TSA56-specific CD4 and CD8 T-cell responses. (A) Human PBMCs were isolated from control individuals and recovered patients and analyzed for antigen-specific T-cell responses by flow cytometry. Gating strategies for the analysis of CD4 or CD8 T cells secreting IFN-γ in an antigen-dependent manner are presented. (B) The kinetic changes of ScaA- or TSA56-specific T cells in the scrub typhus patients were measured by flow cytometry and compared with that of control individuals. The mean values of the relative percentile of IFN-γ-positive T cells among the CD4 or CD8 T-cell population are indicated as red lines, and statistical analysis was performed using ANOVA followed by the Newman–Keuls t-test for comparisons of the values among different groups (*P<0.05; **P<0.01; ***P<0.001). CNT (n=10), Y0 (n=10), Y1 (n=10) and Y2 (n=9).