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. 2017 Dec 6;6(12):e108. doi: 10.1038/emi.2017.96

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Copyright © 2017 The Author(s)

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Virion morphology changes and matrix protein 1 (M1) cytoplasmic disintegration under different pH treatments. (A) Representative transmission electron microscopy (TEM) images of purified wild-type A/WSN/33 (WSN), M(NLS-88R) or M(NLS-88E) pretreated with the indicated pH buffers. Images were acquired under a Zeiss EM 912 transmission electron microscope equipped with a Keenview digital camera. Black and tan arrows indicate M1 layer and spikes, respectively. (B) The percentages of partially spiked virions per ∼100 viral particles blindly counted by two individuals. The data are expressed as the average±SEM. (C) The average M1 thickness in different pH pretreated virions under TEM (n=10 virions). ***P<0.001 by two-way analysis of variance (ANOVA) vs the same virus pretreated with pH 7.4. (D) The M1 cytoplasmic disintegration of different pH pretreated WSN, M(NLS-88R) or M(NLS-88E). Immunofluorescent stained M1 (green) was visualized under FluoView FV10i Confocal Laser Scanning Microscope.