Table 8.
Quantification of insulin sensitivity, resistance and beta cell function in diabetic rats treated with Ocimum gratissimum leaf fractions (250 mg/kg bw) for 28 days.
| Groups | FBS(mg/dL) | HOMA-IR | HOMA-β | Insulin Sensitivity |
|---|---|---|---|---|
| NC | 83.1 ± 6.4 a | 2.7 ± 0.4 a | 52.3 ± 5.6 e | 1.4 ± 0.1 e |
| DC | 489.6 ± 53.8 f | 12.4 ± 2.8 d | 4.0 ± 0.9 a | 0.7 ± 0.1 a |
| OGh | 246.4 ± 19.1 e | 6.5 ± 0.6 c | 12.3 ± 3.0 b | 0.9 ± 0.0 b |
| OGc | 189.8 ± 17.8 c,d | 5.0 ± 0.5 b,c | 16.9 ± 3.1 b | 1.0 ± 0.1 b,c |
| OGe | 215.6 ± 20.2 d,e | 5.8 ± 1.0 c | 14.6 ± 2.3 b | 0.9 ± 0.1 b,c |
| OGb | 166.3 ± 16.9 b,c | 4.8 ± 1.0 b,c | 21.6 ± 3.2 c | 1.0 ± 0.1 c |
| OGa | 222.7 ± 55.4 d,e | 6.2 ± 2.0 c | 15.3 ± 5.4 b | 0.9 ± 0.2 b,c |
| PC | 134.1 ± 12.9 b | 3.86 ± 0.5 a,b | 28.16 ± 5.6 d | 1.1 ± 0.1 d |
Data are presented as mean ± SD of 6 animals per group. Values with different superscript down the column indicate significant difference (p < 0.05). Conversion factor: insulin (1 U/L = 7.174 pmol/L). NC: Normal control; DC: Diabetic control; PC: Positive control (Metformin 500 mg/kg bw); OGh: Ocimum gratissimum n-hexane fraction; OGc: Ocimum gratissimum chloroform fraction; OGe: Ocimum gratissimum ethyl-acetate fraction; OGb: Ocimum gratissimum n-butanol fraction; OGa: Ocimum gratissimum aqueous fraction.