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. 2017 Sep 26;9(4):40. doi: 10.3390/pharmaceutics9040040

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Hepatic cyp450 activities of cyp2b (bupropion), cyp2c (tolbutamide and repaglinide), cyp2d (bufuralol), cyp2e (chlorzoxazone), cyp2j (ebastine), cyp3a (midazolam) and cyp4a (dodecanoic acid) in C57BL6 mice fed a normal diet (ND) or a HFD (LDR, low-diet responders; and HDR, high-diet responders after an eight-week period of treatment). Data were expressed as the mean ± S.D. LDR or HDR vs. ND; * p < 0.05. N/F; activity not found, N/A; Not Available (in vitro incubation could not be determined) and dotted line represents the limit of quantification.

Hepatic cyp450 activities of cyp2b (bupropion), cyp2c (tolbutamide and repaglinide), cyp2d (bufuralol), cyp2e (chlorzoxazone), cyp2j (ebastine), cyp3a (midazolam) and cyp4a (dodecanoic acid) in C57BL6 mice fed a normal diet (ND) or a HFD (LDR, low-diet responders; and HDR, high-diet responders after an eight-week period of treatment). Data were expressed as the mean ± S.D. LDR or HDR vs. ND; * p < 0.05. N/F; activity not found, N/A; Not Available (in vitro incubation could not be determined) and dotted line represents the limit of quantification.