Table 2.
Liver | ND | LDR | HDR |
---|---|---|---|
(nmol/mg protein/min) | |||
Bupropion → Hydroxybupropion | 0.030 ± 0.004 | 0.030 ± 0.004 | 0.023 ± 0.002 ** |
Tolbutamide → Hydroxytolbutamide | 0.22 ± 0.01 | 0.15 ± 0.01 ᵵ | 0.17 ± 0.02 ᵵ |
Repaglinide → M1-repaglinide | 0.050 ± 0.006 | 0.007 ± 0.002 ᵵ | 0.0081 ± 0.0003 ᵵ |
Repaglinide → Hydroxyrepaglinide | 0.0020 ± 0.0001 | 0.0010 ± 0.0002 ᵵ | 0.0013 ± 0.0004 ** |
Bufuralol → Hydroxybufuralol | 0.26 ± 0.05 | 0.19 ± 0.06 | 0.21 ± 0.06 |
Chlorzoxazone → Hydroxychlorzoxazone | 2.0 ± 0.1 | 2.4 ± 0.3 ** | 1.9 ± 0.1 |
Ebastine → Hydroxyebastine and carebastine | 0.044 ± 0.007 | 0.07 ± 0.01 ᵵ | 0.057 ± 0.008 * |
Midazolam → 1′-hydroxymidazolam | 0.32 ± 0.06 | 0.06 ± 0.01 ᵵ | 0.06 ± 0.01 ᵵ |
Dodecanoic acid → 12-hydroxydecanoic acid | 0.19 ± 0.03 | 0.27 ± 0.05 | 0.3 ± 0.1 * |
Cyp450 activities are reported as the rate of metabolite formation in nmol/mg protein/min ± SD (* p < 0.05, ** p < 0.01, ᵵ p < 0.001 compared to ND).