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. 2017 Oct 17;9(4):47. doi: 10.3390/pharmaceutics9040047

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Median and 90% confidence intervals for C_min and (b) 95th quantile for time spent below 1 IU dL⁻¹ (hours per week) for TBW-based dosing regimen administered at different intervals for the combined group (normal + overweight/obese) for both Q48 h (blue) and Monday-Wednesday-Friday (red) dosing schedules. For the Q48 h regimen, all doses are increasing along the X-axis; for the Monday-Wednesday-Friday schedule, only the Friday dose is changing (Monday and Wednesday doses are fixed at 20 IU per kg TBW).