Table 3.
Summary of safety and economic evaluations of different weight metrics used in a Q48 h regimen across BMI subgroups, assuming a baseline factor level of 0.5 IU dL−1. Dose is the dose required to have 95% of patients with a steady state Cmin over 1 IU dL−1. Optimal regimens for each subgroup and the overall population are bolded. IBW: ideal body weight, ABW: adjusted body weight.
| Metric | Normal | Overweight and Obese | All BMI Categories | ||||
|---|---|---|---|---|---|---|---|
| Dose (IU kg−1) |
Mean Consumption (IU per Person per Week) | Dose (IU kg−1) |
Consumption (IU per Person per Week) | Dose (IU kg−1) |
Mean Consumption (IU per Person per Week) | Difference in Consumption from TBW | |
| TBW | 20.0 | 5202 | 14.0 | 5074 | 18.0 | 5603 | - |
| LBW | 25.6 | 5114 | 21.3 | 5028 | 23.8 | 5186 | −417 |
| IBW | 22.2 | 5222 | 20.7 | 4828 | 22.1 | 5176 | −427 |
| ABW25 | 21.7 | 5239 | 20.0 | 5311 | 20.4 | 5171 | −432 |
| ABW40 | 21.1 | 5173 | 18.0 | 5129 | 20.0 | 5301 | −302 |