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. 2017 Dec 20;40(12):889–896. doi: 10.14348/molcells.2017.0263

Fig. 3. Molecular mechanism of paraspeckle formation.

Fig. 3

NEAT1_2 transcription is coupled with the binding of specific proteins to putative RNA elements embedded in NEAT1_2 sequences. Paraspeckle assembly initiates at NEAT1_2 transcription sites, via PSPs that stabilize NEAT1_2 and/or promote interactions with other PSPs, such as several PLD-containing PSPs and SWI/SNF complexes. A high transcriptional level of NEAT1_2 promotes assembly of paraspeckle by concentrating NEAT1_2 at its transcription site. Each paraspeckle contains approximately 50 NEAT1_2 molecules that are organized in several bundles, forming a core-shell spheroidal structure.