Table 4.
Experimentally proved Tamoxifen targets and off-targets predicted by PTS
| Rank | UniProt ID | Target name | Organism | Score |
|---|---|---|---|---|
| 1 | P03372 | ER alpha | Homo sapiens (Human) | 0.82 |
| 2 | P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (Human) | 0.82 |
| 3 | P08684 | mRNA of CYP3A4 | Homo sapiens (Human) | 0.82 |
| 4 | P23458 | JAK1 | Homo sapiens (Human) | 0.81 |
| 5 | P41145 | Kappa-type opioid receptor | Homo sapiens (Human) | 0.81 |
| 6 | Q92731 | ER beta | Homo sapiens (Human) | 0.81 |
| 7 | O14965 | Aurora kinase A | Homo sapiens (Human) | 0.80 |
| 8 | Q96GD4 | Serine/threonine protein kinase 12 | Homo sapiens (Human) | 0.80 |
| 9 | P29597 | TYK2 | Homo sapiens (Human) | 0.80 |
| 10 | P52333 | Tyrosine-protein kinase JAK3 | Homo sapiens (Human) | 0.80 |
| 11 | P10635 | Cytochrome P450 2D6 | Homo sapiens (Human) | 0.80 |