Table 2.

QUADAS-2 Assessment of Risk of Bias for the 8 Included Studies

Study	Risk of Bias				Applicability
	Patient Selection	Index Test	Reference Standard	Flow and Timing	Patient Selection	Index Test	Reference Standard
Rasmussen et al. [2]	✓	✗	✓	✓	✗	✓	✓
Joseph et al. [15]	✓	✗	✗	✓	✗	✓	✓
Khatib et al. [16]	✓	✓	✓	✗	✗	✗	✓
Heriot et al. [17]	✓	✓	✓	✓	✗	✓	✓
Gow et al. [18]	✓	✗	✗	✓	✓	✓	✓
Palraj [19]	✓	✓	✗	✓	✓	✓	✓
Buitron de la Vega et al. [20]	✓	✓	✗	✓	✓	✓	✓
Tubiana et al. [21]	✓	✓	✗	✓	✓	✓	✓

For this review, “Patient Selection” refers to the process by which episodes of sab were identified and selected for inclusion in the reported diagnostic performance statistics; “Index Test” refers to the criteria used to identify patients at very low risk of endocarditis; the “Reference Standard” was the means by which patients received an ultimate diagnosis of endocarditis; and “Flow and Timing” refers to the temporal relationship between the onset of bacteremia, the application of the criteria, and the reference standard.

✓ low risk of bias; ✗ high risk of bias.