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. 2017 Nov 23;18(12):2507. doi: 10.3390/ijms18122507

Figure 5.

Figure 5

All present-study pesticides except trichlorphon and carbaryl inhibited 26S proteasome activity. SH-SY5Y cells stably expressing GFPU were exposed to low concentrations of pesticides for 24 h, and GFP expression levels were detected by immunoblotting (A); relative levels of GFP were measured by ImageJ and analyzed by one-way ANOVA and Dunnett’s test (n = 4) (B); error bars represent SEM. * p < 0.05; ** p < 0.01; *** p < 0.001. β-tubulin was detected as a loading control. (C) SH-SY5Y cells stably expressing GFPU were exposed to pesticides (500 μM paraquat, 1 nM rotenone, 50 μM chlorpyrifos, 50 μM pendimethalin, 50 μM endosulfan, 0.1 μM fenpyroximate, 10 μM tebufenpyrad, 100 μM trichlorphon, 10 μM carbaryl) with 0.1 μM MG132 for 24 h, and GFP expression levels were detected by immunoblotting.