Figure 7.

The influence of an acute administration of berberine (BERB) on the memory impairment induced by an acute injection of scopolamine (SCOP), expressed as latency index (LI) during the short-term (a) or long-term (b) memory acquisition using the PA test in mice. A non-effective dose of BERB (2.5 mg/kg), effective dose of BERB (5 mg/kg) or vehicle were administered 15 min before vehicle or SCOP (1 mg/kg) injection. All drugs were administered 15 min before the first trial and animals were retested 2 h (for short-term memory) or 24 h (for long-term memory) later; n = 8–12; the means ± SEM; * p < 0.05; ** p < 0.01 vs. VEH/VEH-treated group; ^ p < 0.05 vs. VEH/SCOP (1 mg/kg)-treated group; Tukey’s test.