Table 2.
Inhibitory activities and IC50 values (µg/mL) of Hypericum laricifolium Juss. (HL) non-polar and polar extracts against α-glucosidase, aldose reductase (AR), and antioxidants.
| Extracts | α-Glucosidase 1 | AR 2 | DPPH 3 | ABTS 4 | ||||
|---|---|---|---|---|---|---|---|---|
| Inhibition (%) | IC50 (μg/mL) 5 | Inhibition (%) | IC50 (μg/mL) | Inhibition (%) | IC50 (μg/mL) | Inhibition (%) | IC50 (μg/mL) | |
| MC | 11.65 ± 2.1 * | - | 28.9 ± 7.4 * | - | 17.5 ± 0.3 * | - | 14.4 ± 1.3 * | - |
| 70% MeOH | 92.36 ± 1.1 * | 56.6 ± 2.5 | 64.51 ± 1.3 * | 3.3 ± 52 | 93.0 ± 0.1 * | 42.5 ± 0.6 | 78.9 ± 0.6 * | 14.4 ± 1.3 |
| Acarbose | 55.82 ± 2.3 | 367.4 ± 2.1 | - | - | - | - | - | - |
| Quercetin | - | - | 83.7 ± 2.6 | 1.3 ± 3.6 | - | - | - | - |
| L-Ascorbic | - | - | - | - | 99.1 ± 0 | 17.6 ± 0.1 | - | - |
| Trolox | - | - | - | - | - | - | 100 ± 0.1 | 4.6 ± 0.1 |
1 The inhibition rates (%) were calculated at a concentration of 500 μg/mL. 2 The inhibition rates (%) were calculated at a concentration of 10 μg/mL. 3 The inhibition rates (%) were calculated at a concentration of 143 μg/mL except for that of l-ascorbic acid that was calculated at a concentration of 71 μg/mL. 4 The inhibition rates (%) were calculated at a concentration of 33 μg/mL except for that of trolox that was calculated at a concentration of 17 μg/mL. 5 IC50 is defined as the half-maximal inhibitory concentration and data is presented as means ± SD (n = 3). * The asterisk indicates a significant difference compared to positive control group (p < 0.05). MC: Methylene chloride; MeOH: Methanol.