Table 1.

Model comparisons.

Features	In Vitro Models	In Vivo Models
Pros	Easy access to cells Reduced complexity Utilization of human tissue Avoids the need for animals Individual cell responses can be measured	Similar and complex histopathological image Large amount of interacting factors and signaling pathways for manipulation studies or new drugs testing Varied amount of modifications, depending on the purpose of research
Cons	Excludes microenvironment influences and might be misleading Excludes macroenvironmental influences	Differences between human and animal skin and immunity Limitation resulting from the polygene nature of the disease—difficulties in a complete phenotype reconstruction by single mutation Influence of environmental factors
Best use of model	Evaluation of cell physiology, viability, phenotype, function, and responses to stimulators and inhibitors	Suitable for research the multifarious interactions between skin cells, vascular endothelium and immune response