(a) Enzyme activity profiles of rhHNS in spinal cord and brain tissues from four animals after administration of IT rhHNS 14.5 mg. Activity profiles from tissue homogenates are expressed as rhHNS activity with the units nmol/h/mg. Cerebral Cortex (superficial, temporal, and frontal cortex); CNS Nucleus (caudate nucleus, hypothalamus, and thalamus); CNS Structures (cerebellum, corpus callosum, and hippocampus); White Matter (deep and superficial); (b) Enzyme activity profiles of rhHNS in spinal cord and peripheral organs from four animals after administration of IT rhHNS 14.5 mg. Activity profiles from tissue homogenates are expressed as HNS activity with the units nmol/h/mg.