Table 3.

Incorporation of EPA and DHA measured in the plasma membrane when comparing EPA to DHA in human BC cell lines.

Citation	Cell Line	Concentration of EPA or DHA (µM)	Lipid Fraction	Fold Change in Incorporation *
				EPA	DHA
Corsetto, Montorfano, Zava, Jovenitti, Cremona, Berra and Rizzo [24]	MDA-MB-231	230 EPA	Whole cell total lipids	↑15	↓0.2
		200 DHA	Whole cell total lipids	↓0.8	↑7
	MCF-7	230 EPA	Whole cell total lipids	↑10	↑0.5
		200 DHA	Whole cell total lipids	↓0.6	↑9
Corsetto, Cremona, Montorfano, Jovenitti, Orsini, Arosio and Rizzo [17]	MDA-MB-231	230 EPA	Lipid raft PL	↑7	↑1
		200 DHA	Lipid raft PL	↑0.6	↑11
	MCF-7	230 EPA	Lipid raft PL	↑16	↑6
		200 DHA	Lipid raft PL	↓0.3	↑6
Yu [11]	MDA-MB-231	150 EPA + 40 OA + 40 LA	Whole cell PL	↑31	↑1.5
		150 DHA + 40 OA + 40 LA	Whole cell PL	↓0.5	↑11
	MCF-7	150 EPA + 40 OA + 40 LA	Whole cell PL	↑10	↑0.1
		150 DHA + 40 OA + 40 LA	Whole cell PL	↓0.5	↑7
Barascu, Besson, Le Floch, Bougnoux and Jourdan [12]	MDA-MB-231	30 EPA	Whole cell PL	↑13	↑2
		30 DHA	Whole cell PL	↑0.2	↑3

EPA = eicosapentaenoic acid, DHA = docosahexaenoic acid; OA = oleic acid; LA = linoleic acid; FA = fatty acids; PL = phospholipid; “↑” denotes significant increase (p < 0.05); “↓” denotes significant decrease (p < 0.05). * Fold change relative to control conditions.