Table 8.

Comparison of DHA and EPA on total amounts of EGFR and pEGFR in whole cell lipids and lipid rafts in human BC cell lines.

Citation	Cell Line	Concentration of EPA or DHA (µM)	Exposure (Hours)	Change in EGFR *
Cao, Ma, Rasenick, Yeh and Yu [23]	MCF-7	90 EPA	24	NS Δ in whole cell pEGFR:EGFR
		90 DHA		NS Δ in whole cell pEGFR:EGFR
Corsetto, Montorfano, Zava, Jovenitti, Cremona, Berra and Rizzo [24]	MDA-MB-231	230 EPA	72	NS Δ in whole cell EGFR; ↓10% whole cell pEGFR
		230 EPA + 0.01 EGF		NS Δ in whole cell EGFR; ↓52% whole cell pEGFR
		200 DHA		↓20% whole cell EGFR; ↓100% whole cell pEGFR
		200 DHA + 0.01 EGF		NS Δ in whole cell EGFR; ↓100% whole cell pEGFR
Lee, Yun, Koo, Sung, Shim, Ye, Hong and Kim [25]	MDA-MB-231	30, 50 EPA	24	NS Δ in whole cell EGFR ●
		30, 50 DHA		↓whole cell EGFR ●

EPA = eicosapentaenoic acid, DHA = docosahexaenoic acid; EGF = epidermal growth factor; EGFR = epidermal growth factor receptor; pEGFR = phosphorylated EGFR; NS Δ = no significant change; “↓” denotes significant decrease (p < 0.05); “●” = statistical significance was not assessed; “%” = percent change from control condition; * Relative to control conditions.