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. 2017 Dec 6;18(12):2629. doi: 10.3390/ijms18122629

Figure 5.

Figure 5

The expression of genes associated with a versican–hyaluronan rich transitional matrix is modulated by dexamethasone during myoblast differentiation. (A–C) Compared to untreated control cells, 25 nM or 100 nM dexamethasone treatment decreased Tgfb1 (* p < 0.0001 and * p = 0.0001 respectively), Vcan (* p = 0.005 and * p = 0.0006, respectively) and Has2 mRNA transcripts by approximately two-fold (* p < 0.0001 and * p = 0.0001, respectively); (D) Adamts1 gene expression was increased up to three-fold in response to 25 nM and 100 nM dexamethasone treatment (* p = 0.03 and * p < 0.001, respectively); (E,F) Adamts5 and Adamts15 mRNA transcripts were not significantly increased; (G,H) Pcsk6, but not Pcsk3, mRNA transcripts were decreased approximately two-fold following treatment with 25 and 100 nM dexamethasone (* p < 0.0001). (I) Hyal2 mRNA levels were not altered by dexamethasone treatment. Gene expression was determined from n = 3 biological replicates in triplicate. Error bars = S.E.