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. 2017 Dec 6;18(12):2636. doi: 10.3390/ijms18122636

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Arithmetic mean (with standard deviation) heart rate versus time profiles from 0 h to EOS after single-dose administration of cenerimod (Panel (A), N = 6 per dose group, N = 8 for placebo group), single-dose administration in fed or fasted conditions (Panel (B), N = 8), and after multiple o.d. oral doses for 35 days (Panel (C), N = 6 per dose group, N = 8 for placebo group). The black bar represents the treatment duration, left part effect over 24 h and right part over 36 days until EOS. The horizontal dotted lines represent the baseline values. EOS: end-of-study.