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Three-dimensional structure of the IAV M2 ion channel. (A) A monomer of the IAV virus M2 protein TMD showing amino acid residues that face the ion channel; (B) Three-dimensional structure of the M2 ion channel showing the arrangement of four transmembrane domains, and the orientation of pore-lining residues. One M2 monomer is removed to reveal the side chains of the pore-lining residues. The NMR structure with PDB ID 2RLF was used.
