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Schematic representation of phospholipid-arachidonic acid metabolites produced via the major enzymes cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP4A). CYP4A produced 20-hydroxy-eicosatetraenoic acids (20-HETE) metabolite, which is known to promote tumor growth. Legend: phospholipase A2 (PLA2); epoxy-eicosatrienoic acids—(EETs); epoxide hydrolase (sEH); dihydroxy-eicosatrienoic acids (DHETs); hydroperoxy-eicosatetraenoic acid (HPETE); glutathione peroxidase (GPx).
