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. 2017 Dec 13;18(12):2690. doi: 10.3390/ijms18122690

Figure 1.

Figure 1

Effects of simvastatin on ATC cell viability and colony formation. Simvastatin concentration-dependently reduced the viability of SW1736 (A) and 8305C (B) cells. Cells were incubated with 0–20 μM simvastatin for 48 h, and then the cell viability was accessed by MTT assay. (C) Simvastatin (S) and atorvastatin (A) reduced the cell number of SW1736 cells, whereas pravastatin (P) had no effect on the cell number. Cells were incubated with drug compounds for 48 h, and then the relative cell number was accessed by MTT assay. (D) Simvastatin reduced the growth of SW1736 cells in the semi-solid agar. Cells were incubated with 0–20 μM simvastatin for 14 days, and then the cell colonies were stained using crystal violet. (E) Simvastatin did not cause the cytotoxic effect. SW1736 cells were incubated with 0–20 μM simvastatin for 24 h, and then the cytotoxicity was accessed by MTT assay. Values represent the means ± standard error of the mean (SEM) (n = 3). * p < 0.05, different from corresponding control.