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. 2017 Dec 13;18(12):2690. doi: 10.3390/ijms18122690

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Simvastatin reduces cell proliferation and migration and triggers apoptosis in ATC cells. Incubation of ATC cells, SW1736 and 8305C, with simvastatin produces cell proliferation inhibition via inactivation of RhoA/Rac1 small GTPase protein, reduction of protein levels of CCND1, pp-Rb and E2F1, and increases of protein levels of p21^cip and p27^kip. Simvastatin causes cell migration inhibition via repression of Cyr61 expression. In addition, simvastatin induces apoptosis via caspase 3 and PARP activation. gg-Rac1-GTP, geranylgeranylated-Rac1-GTP; gg-RhoA-GTP, geranylgeranylated-RhoA-GTP; pp-Rb, hyperphosphorylated-Rb.