Table 2.

Hereditary human diseases of SLC39A/ZIP transporters.

Genes/Proteins	Mutation Type	OMIM Gene Locus/Phenotype	Chromosomal Location	Disease	References
Slc39a4/ZIP4	Mutation	607059/201100	8q24.3	Acrodermatitis enteropathica (AE)	[17]
Slc39a5/ZIP5	Mutation	608730/615946	12q13.3	Nonsymptomatic high myopia	[49]
Slc39a8/ZIP8	Mutation, Single nucleotide polymorphism (SNP)	608732/616721	4q24	Cerebellar Atrophy Syndrome, Congenital disorder of glycosylation type II	[50,51]
Slc39a13/ZIP13	Mutation	608735/612350	11p11.2	Spondylocheiro dysplastic Ehlers-Danlos syndrome (SCD-EDS)	[32,33]
Slc39a14/ZIP14	Mutation	608736/617013	8q21.3	Childhood-onset parkinsonism-dystonia, Hypermanganesemia with dystonia 2	[52]