Table 5.

Estimated prevalence of autosomal-dominant fibrinogen disorders by ethnicity.

Population	Total Number of Alleles 1	Total Number of Variants	Collective Frequency of Variants	Heterozygote Frequency	Prevalence in 103 Individuals
All	277,144	1524	0.0055	0.011	11
Africans and African Americans	24,036	166	0.0069	0.014	14
Admixed Americans	34,418	176	0.0051	0.010	10
Ashkenazi Jewish	10,152	44	0.0043	0.0087	9
East Asians	18,868	35	0.0019	0.0037	4
Finnish	25,794	44	0.0017	0.0034	3
Non-Finnish Europeans	126,646	922	0.0073	0.015	15
South Asians	30,782	90	0.0029	0.0058	6
Other ethnicities	6466	47	0.0073	0.015	15

Carrier rates were estimated using the gnomAD database, including all null mutations, plus missense variants predicted to be deleterious by 7 of 7 prediction software, plus splicing defects located at intronic positions −3 and +3/+6 and predicted as disrupting by 3 of 3 algorithms (see Section 4). ¹ Discrepancies in the number of alleles are due to slight differences in the number of individuals successfully sequenced for each specific region.