Typical traces of ERG (A); a-wave (B); b-wave (C); and OP amplitude (D) in STZ rats after the instillation of NILnano. One percent NIL were instilled for two weeks (twice a day, 9:00 a.m. and 7:00 p.m.). Open symbols, normal rats; closed symbols, STZ rats. Normal, non-instilled normal rats; Non-instillation, non-instilled STZ rats; Vehicle, vehicle-instilled STZ rats; NILmicro, NILmicro-instilled STZ rats; NILnano, NILnano-instilled STZ rats. n = 5–7. *1
p < 0.05, vs. normal group for each category. *2
p < 0.05, vs. non-instillation group for each category. *3
p < 0.05, vs. vehicle group for each category. *4
p < 0.05, vs. NILmicro group for each category. The retinal dysfunction of STZ rats was attenuated by the instillation of NILnano.