Table 1.
Measured particle amounts in rat lungs.
| Time | Measured Amounts of Nanoparticles in Rat Lungs (μg) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NiO | TiO2 | ||||||||||||||
| Inhalation | |||||||||||||||
| ① NiO-IH-L | ② NiO-IH-H | ③ TiO2-IH-L | ④ TiO2-IH-H | ||||||||||||
| 3D | 40.0 | ± | 2.4 | 132.5 | ± | 9.9 | 41.8 | ± | 3.2 | 249.3 | ± | 12.4 | |||
| 1M | 24.6 | ± | 1.6 | 130.0 | ± | 9.1 | 26.4 | ± | 2.3 | 166.8 | ± | 20.5 | |||
| 3M | 19.0 | ± | 2.8 | 92.4 | ± | 9.5 | 14.8 | ± | 1.6 | 80.9 | ± | 7.5 | |||
| Instillation | |||||||||||||||
| ⑤ NiO-IT-0.2 | ⑥ NiO-IT-1.0 | ⑦ TiO2-IT-0.2 | ⑧ TiO2-IT-0.36 | ⑨ TiO2-IT-1.0 | |||||||||||
| 3D | 136.4 | ± | 6.5 | 738.1 | ± | 49.7 | 126.6 | ± | 12.8 | 262.5 | ± | 6.5 | 825.0 | ± | 40.8 |
| 1W | 128.7 | ± | 15.8 | 645.9 | ± | 194.5 | 130.0 | ± | 6.1 | 240.6 | ± | 24.4 | 835.5 | ± | 29.4 |
| 1M | 126.2 | ± | 5.4 | 676.4 | ± | 46.0 | 78.0 | ± | 4.6 | 130.9 | ± | 44.9 | 521.0 | ± | 159.6 |
| 3M | 95.6 | ± | 13.9 | 539.5 | ± | 119.1 | 31.2 | ± | 1.6 | 53.8 | ± | 10.6 | 278.5 | ± | 80.0 |
| 6M | 59.4 | ± | 15.4 | 465.5 | ± | 112.5 | 14.5 | ± | 2.3 | 28.7 | ± | 6.4 | 138.6 | ± | 39.9 |
IH: inhalation study, IT: instillation study, L: exposure at low concentration, H: exposure at high concentration, Number: instilled amount, D: day, W: week, M: month.