Table 1.
Signaling pathways involved in miR-34b function.
| Pathway | miR-34b Target up Number 1 | DEG Number 2 | Total Number 3 | p-Value |
|---|---|---|---|---|
| TGF-beta signaling pathway | 12 | 12 | 66 | 0.00123255 |
| Axon guidance | 29 | 29 | 165 | 0.000272805 |
| Regulation of actin cytoskeleton | 28 | 28 | 192 | 0.006013617 |
| MAPK signaling pathway | 31 | 31 | 238 | 0.01931642 |
| Vascular smooth muscle contraction | 18 | 18 | 117 | 0.01461593 |
| Tight junction | 19 | 19 | 130 | 0.020507 |
| Oxytocin signaling pathway | 22 | 22 | 146 | 0.009535646 |
| Osteoclast differentiation | 21 | 21 | 122 | 0.002336558 |
| Hippo signaling pathway | 21 | 21 | 133 | 0.006598796 |
| Adherens junction | 15 | 15 | 70 | 0.001029512 |
| Apoptosis | 19 | 19 | 129 | 0.01903818 |
| ErbB signaling pathway | 14 | 14 | 83 | 0.01381979 |
1 The number of genes upregulated by miR-34b; 2 number of differentially expressed genes; 3 number of genes annotated by genomes enriched in the pathways (p < 0.05). DEG: differentially expressed genes; TGF: transforming growth factor; MAPK: mitogen-activated protein kinase; ErbB: Erythroblastic Leukemia Viral Oncogene Homolog.