Table 4.
Hub Gene | Degree | Hub Gene | Degree | Hub Gene | Degree |
---|---|---|---|---|---|
CDK1 | 62 | PNPLA6 [16] | 27 | FARS2 | 20 |
PTEN [17,18] | 61 | SYNJ2 | 27 | FBXO22 | 20 |
BCL2 [19] | 60 | UBE2R2 [20] | 27 | FLT3 | 20 |
POLR2A [21] | 55 | CACNA1D [22,23,24] | 26 | GATA4 [25] * | 20 |
SMARCA2 [26,27] | 55 | CDK6 [28] | 26 | ITSN2 [29] | 20 |
GSK3B [30,31,32,33] | 54 | CHRM2 [34] | 26 | KIF18A | 20 |
ABL1 [35,36,37] | 53 | MTHFD1L [38] ** | 26 | LONRF1 | 20 |
PRKCA [39,40] | 50 | GRIA1 [41] | 25 | NCOA3 | 20 |
bFGF [42] ** | 48 | POLR2H | 25 | PCNT [43] | 20 |
RB1 [44] * | 45 | TJP1 [45] * | 25 | PJA2 | 20 |
KIT [11] | 40 | MAPRE1 [46] * | 24 | SYT1 [47] | 20 |
RAD51 * | 38 | RUNX1 [48] | 24 | TRIM39 | 20 |
SIRT1 [49,50,51] | 38 | UBE2D4 | 24 | WDFY2 [52] ** | 20 |
UBE2D1 [53,54] | 37 | EHHADH | 23 | AK4 | 19 |
DLG1 [55,56] | 36 | IQCB1 | 23 | ASB15 | 19 |
CDC27 [57] | 35 | PPM1B [58] | 23 | ATF2 [29] | 19 |
NEDD4L [59] | 35 | PPP4C [60] * | 23 | BUB1B | 19 |
PRKG1 [61] * | 35 | RAD50 | 23 | DHX15 | 19 |
RAP1A | 34 | SH3GL2 | 23 | DNM3 [62] * | 19 |
CDH2 [63] * | 33 | DCTN1 | 22 | ETV6 | 19 |
GNB5 [64] * | 33 | ERBB4 [65,66] | 22 | FBXL13 [67,68] ** | 19 |
MAPK6 [69] | 33 | FBXO32 | 22 | HECW2 | 19 |
GNG7 [70] | 32 | ITPR1 [71] * | 22 | MEF2C [72] * | 19 |
PTPN11 [73] * | 32 | MLL [74] | 22 | NR3C1 [75] | 19 |
ZBTB16 [76] | 32 | NCOR2 [77] | 22 | BDE4D | 19 |
ADCY2 [78] | 31 | PRKCE [79] | 22 | RNF19B | 19 |
DICER1 [80,81] | 31 | RAD51B | 22 | RNF217 | 19 |
SYNJ1 [82,83,84,85] | 31 | ACTN4 | 21 | RXFP2 | 19 |
CACNA1C [9,52,86,87] | 30 | CCND2 [88,89] | 21 | RYR1 | 19 |
CTTN | 30 | CDH5 | 21 | THBS2 | 19 |
DLG2 [90,91] | 30 | CUL4A [92] * | 21 | AKT3 [93] * | 18 |
MAP3K1 [94] * | 30 | EFCAB13 | 21 | BARD1 | 18 |
RIT2 [95] | 30 | LMO7 | 21 | CTNNA2 [11,96] | 18 |
ANAPC5 [28] | 28 | MITF | 21 | HDAC7 | 18 |
PLCB1 [97,98,99] | 28 | TRIM9 [100] | 21 | ITGAV | 18 |
RAF1 [101] * | 28 | CCND3 | 20 | PARD3 [102] * | 18 |
PARK2 [61] * | 27 | EPHB1 [103] * | 20 | PCSK2 | 18 |
PLCG2 [13,39] | 27 |
* associated with other mental illness ** core hub genes.