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. 2017 Dec 19;18(12):2763. doi: 10.3390/ijms18122763

Table 4.

The gene nodes with a network degree >17.

Hub Gene Degree Hub Gene Degree Hub Gene Degree
CDK1 62 PNPLA6 [16] 27 FARS2 20
PTEN [17,18] 61 SYNJ2 27 FBXO22 20
BCL2 [19] 60 UBE2R2 [20] 27 FLT3 20
POLR2A [21] 55 CACNA1D [22,23,24] 26 GATA4 [25] * 20
SMARCA2 [26,27] 55 CDK6 [28] 26 ITSN2 [29] 20
GSK3B [30,31,32,33] 54 CHRM2 [34] 26 KIF18A 20
ABL1 [35,36,37] 53 MTHFD1L [38] ** 26 LONRF1 20
PRKCA [39,40] 50 GRIA1 [41] 25 NCOA3 20
bFGF [42] ** 48 POLR2H 25 PCNT [43] 20
RB1 [44] * 45 TJP1 [45] * 25 PJA2 20
KIT [11] 40 MAPRE1 [46] * 24 SYT1 [47] 20
RAD51 * 38 RUNX1 [48] 24 TRIM39 20
SIRT1 [49,50,51] 38 UBE2D4 24 WDFY2 [52] ** 20
UBE2D1 [53,54] 37 EHHADH 23 AK4 19
DLG1 [55,56] 36 IQCB1 23 ASB15 19
CDC27 [57] 35 PPM1B [58] 23 ATF2 [29] 19
NEDD4L [59] 35 PPP4C [60] * 23 BUB1B 19
PRKG1 [61] * 35 RAD50 23 DHX15 19
RAP1A 34 SH3GL2 23 DNM3 [62] * 19
CDH2 [63] * 33 DCTN1 22 ETV6 19
GNB5 [64] * 33 ERBB4 [65,66] 22 FBXL13 [67,68] ** 19
MAPK6 [69] 33 FBXO32 22 HECW2 19
GNG7 [70] 32 ITPR1 [71] * 22 MEF2C [72] * 19
PTPN11 [73] * 32 MLL [74] 22 NR3C1 [75] 19
ZBTB16 [76] 32 NCOR2 [77] 22 BDE4D 19
ADCY2 [78] 31 PRKCE [79] 22 RNF19B 19
DICER1 [80,81] 31 RAD51B 22 RNF217 19
SYNJ1 [82,83,84,85] 31 ACTN4 21 RXFP2 19
CACNA1C [9,52,86,87] 30 CCND2 [88,89] 21 RYR1 19
CTTN 30 CDH5 21 THBS2 19
DLG2 [90,91] 30 CUL4A [92] * 21 AKT3 [93] * 18
MAP3K1 [94] * 30 EFCAB13 21 BARD1 18
RIT2 [95] 30 LMO7 21 CTNNA2 [11,96] 18
ANAPC5 [28] 28 MITF 21 HDAC7 18
PLCB1 [97,98,99] 28 TRIM9 [100] 21 ITGAV 18
RAF1 [101] * 28 CCND3 20 PARD3 [102] * 18
PARK2 [61] * 27 EPHB1 [103] * 20 PCSK2 18
PLCG2 [13,39] 27

* associated with other mental illness ** core hub genes.