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. 2017 Dec 19;18(12):2764. doi: 10.3390/ijms18122764

Figure 4.

Figure 4

Effect of vitamin D and analogues on Aβ catabolism. Vitamin D and its analogues influence Aβ-degradation. Total Aβ-degradation in (A) mouse neuroblastoma N2a wt cells (n = 3) and (B) vitamin D deficient mouse brains (n = 5). Calcifediol and its analogues increased the Aβ-degradation compared to solvent control. (C) RT-PCR analysis of NEP expression in SH-SY5Y wt cells (n = 3). (D) NEP activity in N2a cells (n = 8). Error bars represent the standard error of the mean. Asteriks show the statistical significance calculated by unpaired Student’s t test (* p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001).