Table 3.
Involvement of long non-coding RNAs (LncRNAs) in glioma growth and invasion: putative mode of action of a few LncRNAs, with some of their suggested targets.
| LncRNA | Proposed Mode of Action | Some Proposed Targets |
|---|---|---|
| ADAMTS-AS2 | tumor suppressor | DNMT1 [265] |
| CASC 2 | tumor suppressor | miR-21 [268] |
| CRNDE | oncogenic | miR-186, miR-384/PIWIL4 [269,270] |
| GAS 5 | tumor suppressor | miR-196a, miR-222 [263,266,267] |
| H19 | oncogenic (generates miR-675) | Cadherin 13 (CDH13) [271,272,273] |
| HOTAIR | oncogenic | PDCD4, miR-141, SNORD47 [237,263,264,274] |
| HOTTIP | oncogenic | miR-101 [275] |
| HULC | oncogenic | ESM-1; PI3K/AKT/mTOR [276] |
| KCNQ1OT1 | oncogenic | miR-370 [257] |
| LINC0000125 | oncogenic | miR-4775 [277] |
| LINC-POU3F3 | oncogenic | POU3F3; bFGF, bFGFR, VEGFA [278,279] |
| LINK-A | oncogenic | LDH-A [280] |
| MALAT-1(NEAT-2) | oncogenic | miR-101 [281] |
| PLAC 2 | tumor suppressor | ribosomal protein (RP)L36, STAT1 [282] |
| TUG1 | tumor suppressor | miR-26a, miR-144, miR-299 [283,284,285] |
| UCA1 | oncogenic | miR-122 [286,287] |
| XIST | oncogenic | miR-29c, miR-137, miR-152 [288,289,290] |