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. 2017 Dec 28;18(Suppl 16):546. doi: 10.1186/s12859-017-1965-5

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — An illustration of the DRAGON method. This procedure results in the formation of one cluster. One sample is removed at a time, which maximally increases the likelihood function. At the beginning, the likelihood was L ₁ and after two iterations the likelihood became L ₃, where L ₃ > L ₂ > L ₁