Fig. 2.

An example of calculating the DESS for PD-specific gene expression modules. Green indicates increased gene expression, red indicates a decrease. Note that the drug action acts to reverse the direction of gene expression found in the pathological state. Exp. stands for expression value, RP-score stands for the protein relevant score, p. stands for the priority score, P-score stands for the intuitive pharmacology score, DES stands for the Drug Effect Score, module f(ptx) stands for the enrichment score, and the DESS stands for Drug Effect Sum Score