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A tentative model for SALL4-regulated epigenetic mechanism in MLL-r leukemia. a Through interacting with MLL fusion oncoprotein, DOT1L, LSD1 and other epigenetic factors, SALL4 may act as a “guide” in modulating the expression levels of specific downstream gene targets. b SALL4-targetd strategies can disrupt MLL fusion oncoprotein function via dysregulated recruitment of essential epigenetic factors
