Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 23;17(12):2701. doi: 10.3390/s17122701

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Results obtained using the single-shot device (a) 300 µL blood, spiked to a concentration of 1 µM of serotonin is added to the central cavity. An increase in temperature can be observed in both the NIP (red curve) and MIP (black curve) channel due to the medium change. The increase in the MIP is less pronounced as serotonin binds to the MIP, blocking the heat flow in the process, which is translated as a decrease in the differential signal (blue curve), (b) a similar experiment using an analogue—histamine—demonstrates a different behavior. Histamine does not bind to the MIP, and a small increase rather than a decrease in the differential signal can be observed.

Results obtained using the single-shot device (a) 300 µL blood, spiked to a concentration of 1 µM of serotonin is added to the central cavity. An increase in temperature can be observed in both the NIP (red curve) and MIP (black curve) channel due to the medium change. The increase in the MIP is less pronounced as serotonin binds to the MIP, blocking the heat flow in the process, which is translated as a decrease in the differential signal (blue curve), (b) a similar experiment using an analogue—histamine—demonstrates a different behavior. Histamine does not bind to the MIP, and a small increase rather than a decrease in the differential signal can be observed.