Table 3.
Significant (and two almost significant) predictors of asymmetric dimethylarginine (ADMA) serum level and airway resistance (Raw) determined with simple and multiple (for Raw only) linear regression for the whole population of bronchial asthma patients (n = 154)
| Parameter | Coefficient (95% CI) | p |
|---|---|---|
| Simple linear regression of ADMA (log transformed) | ||
| Height | − 0.75 (− 1.25, − 0.26) | 0.003 |
| Disease duration | 0.0061 (0.00062, 0.012) | 0.029 |
| log l-arginine | 0.27 (0.083, 0.45) | 0.005 |
| log SDMA | 0.77 (0.62, 0.93) | < 0.001 |
| log TG | 0.091 (0.0022, 0.18) | 0.045 |
| GFR (normal/low) | 0.12 (0.022, 0.23) | 0.018 |
| FVC% pred | − 0.0037 (− 0.0072, 0.00010) | 0.044 |
| FEV1% pred | − 0.0035 (− 0.0067, − 0.00020) | 0.038 |
| FEF25–75% % pred | − 0.0022 (− 0.0044, 0.000013) | 0.051 |
| log Raw | 0.22 (0.10, 0.34) | < 0.001 |
| log Gaw | − 0.22 (− 0.33, − 0.10) | < 0.001 |
| Simple linear regression of Raw (log transformed) | ||
| Age | 0.0046 (0.00019, 0.0090) | 0.041 |
| Gender | − 0.20 (− 0.33, − 0.075) | 0.002 |
| Height | − 1.22 (− 1.86, − 0.58) | < 0.001 |
| Disease duration | 0.0077 (0.00051, 0.015) | 0.036 |
| Dyslipidemia | 0.18 (0.043, 0.32) | 0.011 |
| Hypertension | 0.19 (0.059, 0.32) | 0.005 |
| BMI | 0.014 − 0.000066, 0.029) | 0.051 |
| Albumin | − 0.028 (− 0.051, − 0.0052) | 0.017 |
| log ADMA | 0.38 (0.17, 0.58) | < 0.001 |
| log SDMA | 0.29 (0.031, 0.54) | 0.028 |
| FVC% pred | − 0.010 (− 0.015, − 0.0059) | < 0.001 |
| FEV1% pred | − 0.14 (− 0.017, − 0.0099) | < 0.001 |
| FEV1/FVC | − 0.018 (− 0.0263, − 0.011) | < 0.001 |
| FEF25–75% % pred | − 0.15 (− 0.24, − 0.062) | 0.001 |
| RV% pred | 0.0022 (0.00033, 0.0042) | 0.022 |
| RV/TLC% pred | 0.0068 (0.0037, 0.0098) | < 0.001 |
| IC/TLC | − 1.22 (− 1.95, − 0.45) | 0.001 |
| SGRQ activity score | 0.0071 (0.0044, 0.0097) | < 0.001 |
| SGRQ impacts score | 0.0044 (0.00094, 0.0079) | 0.013 |
| SGRQ total score | 0.0059 (0.0025, 0.0093) | 0.001 |
| Multiple linear regression of Raw (log transformed) | ||
| log ADMA | 0.22 (0.054, 0.383) | 0.01 |
| FEF25–75% % pred | − 0.009 (− 0.01, − 0.006) | < 0.001 |
| SGRQ activity score | 0.009 (0.004, 0.014) | < 0.001 |
| SGRQ total score | − 0.007 (− 0.012, − 0.001) | 0.019 |
Statistically significant p values are indicated in italic (p < 0.05)
Regression coefficient values are presented with their 95% confidence limits
Significant parameters provided by the simple regression (together with the relevant a priori identified parameters) served as an initial model for the multiple regression analysis