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. 2017 Nov 21;15(1):175–185. doi: 10.1021/acs.molpharmaceut.7b00787

Table 1. Radiolabeling of FSC-ZEGFR:2377 and DFO-ZEGFR:2377 with Zirconium-89 (2.4 nmol, pH 7 at 28 °C and 85°C)a.

  radiochemical yield (RCY %)
  FSC-ZEGFR:2377
DFO-ZEGFR:2377
time [min] 28 °C 85 °C 28 °C 85 °C
10 33.7 ± 10.9 83.6 ± 7.9** 37.9 ± 20.6 96.5 ± 3.0*
30 63.2 ± 11.6 96.8 ± 1.8** 50.2 ± 16.3 97.5 ± 1.4*
45 n.d n.d 62.3 ± 14.4 98.2 ± 1.0*
60 82.7 ± 10.3 97.7 ± 0.1 74.4 ± 9.9 98.5 ± 0.6*
90 88.1 ± 7.4 98.6 ± 1.0 81.8 ± 0.2 n.d
120 91.9 ± 5.8 n.d 83.1 ± 2.6 n.d
a

Data were calculated from ITLC measurement of the nonpurified bioconjugates and are presented as mean ± standard deviation (n = 4), statistical analysis was performed using the Student’s t test with P values indicating very significant (** P < 0.01) and significant (* P < 0.05) difference between various temperature.