Table 4. Tumor-to-Organ Ratios of 89Zr-FSC-ZEGFR:2377 and 89Zr-DFO-ZEGFR:2377 in BALB/C Nude Mice Bearing EGFR-Expressing A431 Tumor Xenograft (Mean ± SD; n = 4)a.
|
89Zr-FSC-ZEGFR:2377 (radiolabeling at 85 °C) |
89Zr-DFO-ZEGFR:2377 (radiolabeling at 85 °C) |
89Zr-DFO-ZEGFR:2377 (radiolabeling
at RT)42 |
||||
|---|---|---|---|---|---|---|
| organs | 3 h | 24 h | 3 h | 24 h | 3 h | 24 h |
| blood | 9.0 ± 3.3§ | 17.5 ± 5.6§ | 10.6 ± 2.4# | 13.7 ± 2.0# | 2.2 ± 0.3 | 3.7 ± 0.6 |
| salivary gland | 7.3 ± 2.1§ | 5.0 ± 1.6 | 7.3 ± 1.7# | 5.1 ± 1.6 | 4.4 ± 0.8 | 3.2 ± 0.5 |
| lung | 5.9 ± 1.3§ | 6.0 ± 1.2§ | 7.2 ± 1.3# | 5.7 ± 1.4# | 2.7 ± 0.5 | 2.7 ± 0.4 |
| liver | 1.3 ± 0.4 | 0.9 ± 0.2 | 1.9 ± 0.3*,# | 1.4 ± 0.3*,# | 1.1 ± 0.2 | 1.0 ± 0.1 |
| spleen | 5.6 ± 1.2 | 3.8 ± 0.4 | 6.6 ± 0.6# | 3.5 ± 0.8 | 5.3 ± 0.4 | 3.2 ± 1.0 |
| colon | 6.4 ± 1.3§ | 4.5 ± 1.2 | 5.4 ± 1.1 | 4.2 ± 1.2 | 3.9 ± 0.9 | 3.1 ± 1.2 |
| kidney | 0.03 ± 0.006 | 0.02 ± 0.00 | 0.02 ± 0.003 | 0.01 ± 0.00 | 0.02 ± 0.003 | 0.01 ± 0.00 |
| muscle | 27.9 ± 4.9§ | 21.9 ± 2.2§ | 28.4 ± 4.7# | 18.6 ± 3.2# | 13.6 ± 1.3 | 10.3 ± 1.2 |
| bone | 8.5 ± 1.8§ | 5.6 ± 1.8§ | 9.3 ± 2.6# | 3.6 ± 1.3# | 4.6 ± 0.4 | 1.6 ± 0.1 |
a
Statistical analysis was performed using the Student’s t test with P values indicating significant (P < 0.05) difference (*) between 89Zr-FSC-ZEGFR:2377 (85 °C) and 89Zr-DFO-ZEGFR:2377 (85 °C), (§) between 89Zr-FSC-ZEGFR:2377 (85 °C) and 89Zr-DFO-ZEGFR:2377 (RT) and (#) between 89Zr-DFO-ZEGFR:2377 (85 °C) and 89Zr-DFO-ZEGFR:2377 (RT) at corresponding time points.